Physical Lens on the Cell | Physical Lens on the Cell

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Physical Lens on the Cell

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\newcommand{\avg}[1]{\langle #1 \rangle}<br>\newcommand{\cc}[1]{[\mathrm{#1}]^{\mathrm{cell}}}<br>\newcommand{\cgdp}{\mathrm{C \! \cdot \! GDP}}<br>\newcommand{\cgtp}{\mathrm{C \! \cdot \! GTP}}<br>\newcommand{\comb}[1]{{#1}^{\mathrm{comb}}}<br>\newcommand{\conc}[1]{[\mathrm{#1}]}<br>\newcommand{\conceq}[1]{[\mathrm{#1}]^{\mathrm{eq}}}<br>\newcommand{\concss}[1]{[\mathrm{#1}]^{\mathrm{ss}}}<br>\newcommand{\conctot}[1]{[\mathrm{#1}]_{\mathrm{tot}}}<br>\newcommand{\cu}{\conc{U}}<br>\newcommand{\dee}{\partial}<br>\newcommand{\dgbind}{\Delta G_0^{\mathrm{bind}}}<br>\newcommand{\dgdp}{\mathrm{D \! \cdot \! GDP}}<br>\newcommand{\dgtp}{\mathrm{D \! \cdot \! GTP}}<br>\newcommand{\dmu}{\Delta \mu}<br>\newcommand{\dphi}{\Delta \Phi}<br>\newcommand{\dplus}[1]{\mbox{#1}^{++}}<br>\newcommand{\eq}[1]{{#1}^{\mathrm{eq}}}<br>\newcommand{\fidl}{F^{\mathrm{idl}}}<br>\newcommand{\idl}[1]{{#1}^{\mathrm{idl}}}<br>\newcommand{\inn}[1]{{#1}_{\mathrm{in}}}<br>\newcommand{\ka}{k_a}<br>\newcommand{\kcat}{k_{\mathrm{cat}}}<br>\newcommand{\kf}{k_f}<br>\newcommand{\kfc}{k_{fc}}<br>\newcommand{\kftot}{k_f^{\mathrm{tot}}}<br>\newcommand{\kd}{K_{\mathrm{d}}}<br>\newcommand{\kdt}{k_{\mathrm{dt}}}<br>\newcommand{\kdtsol}{k^{\mathrm{sol}}_{\mathrm{dt}}}<br>\newcommand{\kgtp}{K_{\mathrm{GTP}}}<br>\newcommand{\kij}{k_{ij}}<br>\newcommand{\kji}{k_{ji}}<br>\newcommand{\kkeq}{K^{\mathrm{eq}}}<br>\newcommand{\kmmon}{\kon^{\mathrm{ES}}}<br>\newcommand{\kmmoff}{\koff^{\mathrm{ES}}}<br>\newcommand{\kconf}{k_{\mathrm{conf}}}<br>\newcommand{\konf}{k^{\mathrm{on}}_{\mathrm{F}}}<br>\newcommand{\koff}{k_{\mathrm{off}}}<br>\newcommand{\kofff}{k^{\mathrm{off}}_{\mathrm{F}}}<br>\newcommand{\konu}{k^{\mathrm{on}}_{\mathrm{U}}}<br>\newcommand{\koffu}{k^{\mathrm{off}}_{\mathrm{U}}}<br>\newcommand{\kon}{k_{\mathrm{on}}}<br>\newcommand{\kr}{k_r}<br>\newcommand{\ks}{k_s}<br>\newcommand{\ku}{k_u}<br>\newcommand{\kuc}{k_{uc}}<br>\newcommand{\kutot}{k_u^{\mathrm{tot}}}<br>\newcommand{\ktd}{k_{\mathrm{td}}}<br>\newcommand{\ktdsol}{k^{\mathrm{sol}}_{\mathrm{td}}}<br>\newcommand{\minus}[1]{\mbox{#1}^{-}}<br>\newcommand{\na}{N_A}<br>\newcommand{\nai}{N_A^i}<br>\newcommand{\nao}{N_A^o}<br>\newcommand{\nb}{N_B}<br>\newcommand{\nbi}{N_B^i}<br>\newcommand{\nbo}{N_B^o}<br>\newcommand{\nc}{N_{C}}<br>\newcommand{\nl}{N_L}<br>\newcommand{\nltot}{N_L^{\mathrm{tot}}}<br>\newcommand{\nr}{N_R}<br>\newcommand{\nrl}{N_{RL}}<br>\newcommand{\nrtot}{N_R^{\mathrm{tot}}}<br>\newcommand{\out}[1]{{#1}_{\mathrm{out}}}<br>\newcommand{\plus}[1]{\mbox{#1}^{+}}<br>\newcommand{\rall}{\mathbf{r}^N}<br>\newcommand{\rn}[1]{\mathrm{r}^N_{#1}}<br>\newcommand{\rdotc}{R \!\! \cdot \! C}<br>\newcommand{\rstarc}{R^* \! \! \cdot \! C}<br>\newcommand{\rstard}{R^* \! \! \cdot \! D}<br>\newcommand{\rstarx}{R^* \! \! \cdot \! X}<br>\newcommand{\ss}{\mathrm{SS}}<br>\newcommand{\totsub}[1]{{#1}_{\mathrm{tot}}}<br>\newcommand{\totsup}[1]{{#1}^{\mathrm{tot}}}<br>\newcommand{\ztot}{Z^{\mathrm{tot}}}<br>% Rate notation: o = 1; w = two; r = three; f = four<br>\newcommand{\aow}{\alpha_{f}}<br>\newcommand{\awo}{\alpha_{u}}<br>\newcommand{\kow}{\kf} % {\kf(12)}<br>\newcommand{\kwo}{\ku} % {\ku(21)}<br>\newcommand{\kor}{\conc{C} \, \konu} % \konu(13)}<br>\newcommand{\kwf}{\conc{C} \, \konf} % \konf(24)}<br>\newcommand{\kro}{\koffu} % {\koffu(31)}<br>\newcommand{\kfw}{\kofff} % {\kofff(42)}<br>\newcommand{\krf}{\kfc} % {\kfc(34)}<br>\newcommand{\kfr}{\kuc} % {\kuc(43)}<br>\newcommand{\denom}{ \krf \, \kfw + \kro \, \kfw + \kro \, \kfr }

Goals<br>Understand the physical driving forces behind cellular processes<br>Organize cellular processes into physical categories to facilitate transfer of understanding<br>Focus on deep understanding and specific examples because learning all cell biology is not an option<br>Philosophy<br>All processes in the cell necessarily are driven by physical rules. Otherwise, they wouldn't happen.<br>Biologists and physicists should understand how and why.<br>The key physical principles can be understood through a relatively simple mass-action picture of non-equilibrium kinetics.

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Chemical Physics

Physical / Molecular Processes

Energy Economy

Molecular Machinery

Cell Biology Phenomena

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