YC Requests for Startups, 2008–2026

Y Combinator Requests for Startups, 2008–2026

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Row IDYear / CohortTitlePlain-English SummarySourceAuthor / RequesterTheme Family<br>12026 SummerAI for Low-Pesticide AgricultureTools that help farmers produce more with fewer pesticides while improving yield.SourceGarry TanAgTech / AI22026 SummerAI-Native Discovery EnginesAI-native systems that help researchers propose and validate hypotheses.SourceJon XuAI for science32026 SummerAI-Native Service CompaniesCompanies that sell completed services using AI, rather than selling software tools.SourceGustaf AlströmerAI services42026 SummerAI Personalized MedicinePersonalized diagnostics, risk assessment and therapies using personal health data and agents.SourceAnkit GuptaHealthcare AI52026 SummerCompany BrainA living knowledge layer that structures company know-how for reliable AI automation.SourceTom BlomfieldEnterprise AI62026 SummerCounter-Swarm DefenseTechnology to defend against coordinated drone swarms.SourceTyler BosmenyDefense tech72026 SummerDynamic Software InterfacesSoftware interfaces users can heavily customize using coding agents.SourceAnkit GuptaSoftware UX / AI82026 SummerElectronics in SpaceCompute and inference hardware optimized for space environments.SourcePhilip JohnstonSpace / chips92026 SummerHardware Supply ChainFaster design-to-part iteration loops and supply-chain tooling for hardware teams.SourceNicolas DessaigneHardware / manufacturing102026 SummerIndustrial Capabilities in SpaceIndustrial production and raw-material extraction on the moon or in space.SourceAdi OlteanSpace / industrial112026 SummerInference Chips for Agent WorkflowsInference silicon optimized for agent loops, tool calls, branching and context switching.SourceDiana HuAI infrastructure / chips122026 SummerSaaS ChallengersAI-native challengers to legacy SaaS categories.SourceJared FriedmanAI-native SaaS132026 SummerSoftware for AgentsAPIs, MCPs, CLIs and documentation built for AI agents as users.SourceAaron EpsteinAgent infrastructure142026 SummerStartups That Want to Sell to Huge CompaniesStartups using AI to sell and deliver into massive enterprises.SourceHarshita Arora and Brad FloraEnterprise sales152026 SummerSupply Chain 2.0 for SemiconductorsModern software for wafer allocation, packaging constraints and chip supply chains.SourceDiana HuSemiconductor supply chain162026 SummerThe AI Operating System for CompaniesA connective layer that makes company work legible to AI and turns artifacts into specs agents can execute.SourceDiana HuEnterprise AI / PM172026 SpringCursor for Product ManagersAI workspace for product teams to synthesize research, usage, feedback and create coding-agent-ready tasks.SourceAndrew MiklasProduct management AI182026 SpringAI-Native Hedge FundsHedge funds built around AI agents from day one.SourceCharlie Holtz, ConductorAI finance192026 SpringAI-Native AgenciesAgencies whose delivery model and margins are transformed by AI.SourceAaron EpsteinAI services202026 SpringStablecoin Financial ServicesFinancial services built on stablecoin rails.SourceDaivik Goel, ShorFintech / stablecoins212026 SpringAI for GovernmentAI tools to process forms, applications and government paperwork faster.SourceTom BlomfieldGovtech222026 SpringModern Metal MillsSoftware-defined, flexible metal mills for modern supply chains.SourceZane Hengsperger, Nox MetalsIndustrial / manufacturing232026 SpringAI Guidance for Physical WorkCamera/glasses-based AI guidance for workers doing physical tasks.SourceDavid LiebAI for field work242026 SpringLarge Spatial ModelsModels specialized in 3D geometry, physical manipulation and spatial reasoning.SourceRyan McLinko, AstranisAI foundation models252026 SpringInfra for Government Fraud HuntersSoftware to help investigators package and pursue government fraud cases.SourceGarry TanGovtech / fraud262026 SpringMake LLMs Easy to TrainBetter tooling, APIs, datasets and environments for training specialized LLMs.SourceGabriel Birnbaum, YNAI infrastructure272026Techno-Industrialist RFSStartups applying modern software to the stack of industrial production.SourceYC / Reindustrialize Summit / New American Industrial AllianceIndustrial technology282025 FallRetraining Workers for the AI EconomyTraining skilled workers needed for data centers, semiconductors and AI-era infrastructure.SourceHarj TaggarWorkforce / AI infrastructure292025 FallVideo Generation as a PrimitiveTreat AI-generated video as a core primitive for media, gaming, commerce and simulation.SourceDavid LiebGenerative video302025 FallThe First 10-person, $100B CompanyExtremely high-output tiny teams built around AI leverage.SourceAaron EpsteinAI-native company building312025 FallInfrastructure for Multi-Agent SystemsTools for building, monitoring and debugging multi-agent systems.SourcePete KoomenAgent infrastructure322025 FallAI Native Enterprise SoftwareRebuilding major enterprise categories around AI-native...